Maximizing Risk of Cardiac Arrest with Blood Pressure Drugs

One of the recent studies has revealed that intake of common blood pressure drugs results in the increased risk of cardiac arrest.

In medical terms, a cardiac arrest occurs when the heart stops the pumping of blood in your body. Not resulting in a proper and immediate treatment can be hazardous for a person with cardiac arrest.

The study focused on finding out whether drugs such as Nifedipine and Amlodipine, Dihydropyridines are linked with the cardiac arrest or not. These drugs are generally used to combat the issues of blood pressure and angina. The researchers used around 30mg and 60 mg of Nifedipine and the dose of Amlodipine used was 5mg and 10mg for the execution of this study.

Initially, the in-take starts with a lower dose and then the dose is increased according to the chest pain and pressure hike. According to Hanno Tan, a cardiologist at the American Medical Center in the Netherlands, states “The findings require to be simulated in other studies or areas before an action is taken by the patients or doctors.”


Cardiac Arrest – A Severe Health Problem Across the World

The American Heart Association has recorded that approximately 4,75,000 die per year due to a cardiac arrest. When compared to prostate cancer, breast cancer, pneumonia, HIV, etc. a large number of people are prone to the death caused by cardiac arrest.

Major Warnings of Cardiac Arrest

There are no specific signs that indicate the occurrence of a cardiac arrest. It can happen at any time but ensure that no delay in receiving the treatment is made. When a person experiences the cardiac arrest: they won’t respond, loss of consciousness, and difficulty or no breathing.

BP controlling drugs can increase the risk of cardiac arrest

Study

With the assistance of ESCAPE_NET data, a study was conducted to find out the role of common drugs in the occurrence of cardiac arrest. Most of the doctors prescribe drugs such as Dihydropyridines to treat blood pressure and Angina.


Angina – A chest pain which is associated with the minimized blood flow to your heart

The project focused on two Dihydropyridines – Nifedipine and Amlodipine. The researchers had well-prepared access to the data of more than 10000 people who were consuming Dihydropyridines.

The analysis highlighted the fact that people who consumed Nifedipine were more likely to experience an ‘out-of-the-hospital’ heart attack rather than people who were not consuming Dihydropyridines.

Reason for Such Occurrence

The researchers further went to discovered the reason behind why the actions of both the drugs varied. Even though both follow the same procedure, why does one enhances the risk of cardiac arrest and why the second one doesn’t make a difference. Generally, the Dihydropyridines continues its action by preventing the L-type of Calcium passages. When these channels get blocked, the ability of cardiac cells is lessened. The action-potential of cardiac cells get affected largely.

Action Potential – Refers to the changes that occur in a membrane which is related to the impulse transmission. Basically, they happen in the muscle cells and nerves. It might enhance the arrhythmias which can increase the risk of cardiac arrest.

In precise, high dosage of Nifedipine can lessen the ‘Action Potential’, more than high-dosage of Amlodipine.

The study focusses on the fact that increased dosage of Nifedipine can maximize the cardiac arrest threat because of the severe cardiac arrhythmia, whereas Amlodipine does not increase the risk.

In the present medical or healthcare sector, the two drugs – Nifedipine and Amlodipine are mostly preferred by almost every cardiologist and the suggestion might vary according to the personal experience or other reasons stated by the prescriber.